PCOS & Weight Gain

• PCOS affects hormone balance, ovulation, and metabolism
• Insulin resistance is common and increases the risk of weight gain and prediabetes
• A weight loss of 5 to 10 percent can improve cycles, ovulation, and metabolic health
• GLP-1 receptor agonists can help eligible adults reduce appetite and improve insulin sensitivity (link to: /weight-loss/clinical/eligibility-weight-loss-medication)
• Ongoing clinical follow-up supports safe, steady progress

PCOS symptoms vary but often include irregular periods or absent ovulation, acne, excess hair growth, and scalp hair thinning. Many people notice gradual weight gain, particularly around the abdomen, along with sugar cravings and low energy. Emotional effects such as low mood and anxiety are common and may influence eating behaviours.

PCOS has genetic and hormonal drivers. Insulin resistance plays a central role by increasing insulin levels, which can raise androgen production and disrupt ovulation. Weight gain can worsen insulin resistance, creating a cycle that makes weight loss harder. Family history, sedentary lifestyle, and sleep problems can increase risk.

Doctors diagnose PCOS based on a combination of symptoms, blood tests, and pelvic ultrasound where indicated. They may check testosterone, LH and FSH, and assess metabolic risk with fasting glucose or HbA1c, lipids, and blood pressure. Screening helps guide treatment choices and monitor long-term health.

A comprehensive approach works best. Nutrition and activity plans target insulin resistance and support gradual weight reduction. In eligible adults, GLP-1 receptor agonists such as semaglutide and tirzepatide can reduce appetite and improve glycaemic control. Some patients may also use metformin to address insulin resistance. For cycle control and acne, clinicians may consider hormonal treatments. Evidence summaries for GLP-1 therapy are available in our trials overview.

Focus on balanced meals with protein and fibre to stabilise blood sugar. Plan portions, include non-starchy vegetables, and limit sugary drinks and ultra-processed snacks. Regular physical activity and resistance training improve insulin sensitivity. Prioritise sleep and manage stress to reduce cravings and support hormone balance.

Seek medical advice if you have irregular periods, difficulty conceiving, persistent acne or excess hair growth, or rapid weight gain. A clinician can confirm diagnosis, check for metabolic risks, and recommend a tailored plan. Early intervention helps protect long-term fertility and cardiometabolic health.

People trying to conceive may need adjusted treatment plans and specialist fertility input. Those with severe insulin resistance, sleep apnoea, or thyroid disease require careful monitoring. For anyone planning pregnancy, clinicians will advise on safe timing and medication choices, including when GLP-1 therapy should be paused.

PCOS cannot always be prevented, but maintaining a healthy weight and active lifestyle lowers the risk of complications. Building structured routines around meals, movement, and sleep helps stabilise insulin levels and reduce symptoms. Supportive environments at home and work make long-term habits easier to maintain.

PCOS is a long-term condition that benefits from regular review. Track weight, waist, cycles, and energy levels, and reassess goals at set intervals. If using GLP-1 medication, attend follow-up appointments to monitor progress and adjust dosing safely alongside nutrition and activity plans.

Medicspot provides clinical assessment and treatment for adults with PCOS and weight concerns. Where appropriate, we prescribe NICE and MHRA approved GLP-1 medication and combine it with nutrition and coaching support. Plans are personalised to improve metabolic health, support cycle regulation, and help you reach sustainable goals.

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire alongside other independently validated medical information about you and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases the clinicians may contact you for additional information. See Terms of Service for more information.