Mounjaro 10mg Injection

The Mounjaro 10mg dose is typically Step 4 in the standard titration schedule. After at least four weeks on 7.5mg, your clinician may approve moving up to 10mg if:

• Your weight loss has plateaued and you need additional support
• Appetite suppression has reduced before your next injection
• You’re tolerating previous doses well with only mild side effects

At this level, tirzepatide’s dual GLP-1 and GIP hormone effects are more fully activated, often leading to greater appetite control and enhanced weight loss

A Mounjaro 10mg pen (lasting 4 weeks) costs £289.

This includes ongoing medical oversight and access to Medicspot’s coaching support, designed to help you stay consistent and manage side effects effectively.

Some patients may remain on 10mg for several months, depending on their goals and how well they tolerate the dose. Your clinician will guide you on when it’s time to adjust.

Potential benefits include:

• Stronger appetite control – Many people find they feel full sooner and stay full longer.
• Greater average weight loss – Studies show continued and sometimes faster weight reduction at this stage¹.
• Improved glucose control – For patients with insulin resistance or type 2 diabetes, this dose can further improve blood sugar levels². Even if you don’t have diabetes your body will be processing sugar more effectively.

Possible side effects include:

• Nausea or stomach discomfort – Often mild and temporary, settling within a couple of weeks.
• Bloating or constipation – You can combat this by increasing fluids and fibre intake, and staying active.
• Fatigue or low energy – This is common during the first week of any dose increase.

At this point, your body is working more efficiently than ever.

At higher doses, Mounjaro works more strongly on the hormones that control hunger and fullness. This helps you feel satisfied after smaller meals and makes it easier to eat less without feeling deprived.

Weight loss becomes more consistent as your body adjusts and your metabolism starts to work more efficiently³.

Everyone’s experience is different. Some find this dose easy to tolerate, while others may prefer to stay here for longer before considering any increase.

“just done first week on 10 and it’s been a good one”

 

“started 10mg and big decrease in appetite”

 

“stayed on 10mg as felt i was hardly easting or drinking much at all last 4 weeks and don’t want to lose too much weight too quickly”

You might be ready to move up from 7.5mg to the 10mg pen if:

• You’ve been stable on 7.5mg for at least 4 weeks
• You’re no longer feeling consistent appetite suppression
• Your weight loss has slowed or plateaued
• You’re tolerating side effects well

You might need to move down from 12.5mg to 10mg if:

• You’re losing weight too quickly
• You’re struggling with nausea, fatigue, or dehydration
• You’ve reached your goal weight and want to maintain your results
• Your struggling to eat enough to maintain your nutritional needs

Even though your appetite is smaller, your nutrition matters more than ever.

• Focus on high-protein, nutrient-dense meals
• Keep your hydration consistent (aim for 1.5-2 L daily)
• Include light daily movement – walking, stretching, or low-impact exercise helps digestion and energy
• Prioritise sleep and recovery as your body continues to adapt

Reaching the 10mg stage of your Mounjaro journey is a major achievement. It’s often where members start to notice lasting changes, not just in appetite, but in confidence, energy, and day-to-day wellbeing.

As your body adapts to this stronger dose, focus on consistency over perfection. Give yourself time to adjust, prioritise hydration and balanced meals, and remember that sustainable progress matters more than speed.

If you experience side effects, they’re usually temporary, but your clinician and coach are always here to help you manage them safely.

Dr Jackir Hussain is a GP with over 14 years of experience, having earned his medical degree from the University of Manchester. He has worked across a wide range of primary care settings, including NHS surgeries, unscheduled care services, homeless shelters, and telemedicine. Dr Hussain is passionate about delivering accessible, patient-centred care and helping individuals take practical steps toward improving their health. In his role at Medicspot, he brings a wealth of frontline experience and a calm, compassionate approach to supporting patients on their weight management journey.

Dr Abby Hyams grew up in Manchester and completed her medical training in Bristol. She has been a GP for 19 years, spending many of those as a partner in an NHS practice in Hemel Hempstead. Dr Hyams loves being a GP because of the wide spectrum of people she encounters every day and the opportunity to make a meaningful difference in their lives. She has a particular passion for supporting patients with weight loss and promoting positive behaviour change, helping individuals build sustainable habits that improve their long-term health and wellbeing.

¹ Jastreboff AM, Aronne LJ, Ahmad NN, et al. Tirzepatide once weekly for the treatment of obesity. The New England Journal of Medicine. Last accessed November 2025. [https://www.nejm.org/doi/full/10.1056/NEJMoa2206038]

² National Institute for Health and Care Excellence (NICE). Tirzepatide for managing overweight and obesity (Technology appraisal guidance TA1026). Published 23 Dec 2024. Last accessed November 2025. [https://www.nice.org.uk/guidance/ta1026/chapter/1-Recommendations]

³Aronne LJ, Sattar N, Horn DB, et al. Continued treatment with tirzepatide for maintenance of weight reduction in adults with obesity: the SURMOUNT-4 randomized clinical trial. JAMA. 2024;331(1):38-48. doi:10.1001/jama.2023.24945. Last accessed November 2025. [https://jamanetwork.com/journals/jama/fullarticle/2812936]

Eli Lilly and Company Ltd. “Mounjaro® KwikPen 10 mg solution for injection in pre-filled pen – Summary of Product Characteristics (SmPC).” Electronic Medicines Compendium (eMC). Last accessed November 2025. [https://www.medicines.org.uk/emc/product/15484/smpc]

Diabetes UK. Mounjaro (tirzepatide) – uses, how it works and side effects. Last accessed November 2025. [https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/tablets-and-medication/glp-1/mounjaro]

This article is for general information only and should not be used for the diagnosis or treatment of medical conditions. Medic Spot Limited has used all reasonable care in compiling the information but makes no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. In the event of an emergency, please call 999 for immediate assistance.

There is no guarantee of a specific weight loss medication being prescribed. Clinicians will review your online questionnaire and will recommend the most appropriate weight loss treatments for you based on your answers. In some cases the clinicians may contact you for additional information. See our Terms of Service for more information.